Q) Describe the mechanism of action of all enzymes
Main points | |
Key idea: | What are enzymes |
·Biological catalysts - speed up rate of chemical rx ·by lowering activation energy of rx | |
Key idea: | Formation of the enzyme-substrate (ES) complex |
·Effective collision b/w substrate & enz mol ·Substrate binds to active site (AS) of enz by ionic or/& H bonds for transient period | |
Key idea: | Lowering of activation energy through formation of the ES complex |
·Due to stress to bonds in substrate mol – become easily broken ·Or diff substrate mol bound at AS in close proximity & correct orientation - faciliates formation of bonds b/w mol | |
Key idea: | Specificity of enzyme action |
·Ref to induced fit hypothesis to explain specificity of enz action Details: ·Shape of AS not complementary to substrate initially ·Upon binding to AS, substrate induces conformation change ·Result - AS now fits substrate ·Ref to complementary binding of substrate to AS of enz | |
Key idea: | Enzyme is recycled |
·When product is formed, it no longer fits AS & will leave ·Enz is re-used for other rx | |
Comments: (i) Visualize the answer with the aid of a labelled diagram. (ii) Verbalize the answer + write down the main points w/o referring to the answer (use abbreviations) (iii) Read again within the next 24h & once more within 72h (do not spend more than 10min) | |
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