Saturday, November 12, 2011

Topic Biomolecule & cell signalling

Q) Describe the differences between glycogen and glucagon
Main points
Key idea:
Type of molecule + building blocks + bonds
Glycogen
·  Polysaccharide, made up of many α glucose
·Joined by α-1,4 glycosidic bonds
·Highly branched struc
·Ref to α-1,6 glycosidic bonds at branch pts
Glucagon
·Protein, made up of aa
·Joined by peptide bonds
·Globular struc due to infolding of polypep chain upon itself
·Ref to interactions (e.g. H, ionic, disulphide & hydrophobic) b/w R gps of faraway aa residues
Key idea:
Role + location
Glycogen
·Energy storage mol
· Stored in muscle & liver
Glucagon
·Hormone; regulates bl glucose level
·Stored in the α cells, islets of Langerhans, pancreas
Key idea:
Solubility in water
Glycogen
·Soluble in H2O; can be transported via blood to targe cells/tissue
·Infolding of polypep affect distribution of aa
·Ref to polar aa residues on ext surf of mol; non-polar aa residues in the interior
Glucagon
·Insoluble in H2O
·Ref to polar OH gps project into mol
·Ref to large size as a contributing factor too
Comments:
(i) Visualize the answer with the aid of a labelled diagram.
(ii) Verbalize the answer + write down the main points w/o referring to the answer (use abbreviations)
(iii) Read again within the next 24h & once more within 72h (do not spend more than 10min)

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